Allergic Encephalomyelitis

Alpha-fetoprotein suppresses experimental allergic encephalomyelitis.

Experimental allergic encephalomyelitis (EAE), induced in guinea pigs by immunization with myelin basic protein (MBP) or whole CNS homogenate was successfully treated, as well as partially prevented, by daily administration of fetal alpha-fetoprotein (alpha FP). alpha FP which is produced in high quantities during pregnancy can inhibit both the cell-mediated immune response to MBP and the bindi...

Suppression of Allergic Encephalomyelitis I N Rats

Certain tissues, e.g. brain, thyroid, and testis, have long been known to possess antigenic activity and, when injected into experimental animals, elicit circulating antibodies which react specifically with the corresponding tissue in vitro (1-7). I t is also known that animals injected with these tissues emulsified in Freund's adjuvant may develop striking tissue damage restricted to the organ...

Metabolomics approaches in experimental allergic encephalomyelitis.

A myelin basic protein (MBP)-induced experimental allergic encephalomyelitis (EAE) involves paraplegia due to a reversible thoracolumbar spinal cord impairment. The aims of this study were thus to find significant metabolic biomarkers of inflammation and identify the site of inflammation in the central nervous system (CNS) during the acute signs in of the disease using metabolomics. All the EAE...

Experimental Allergic Encephalomyelitis in Oxygen Immunosuppression : Modification

MR of acute experimental allergic encephalomyelitis.

Acute experimental allergic encephalomyelitis, an animal model of CNS inflammatory and demyelinating disease, was produced in guinea pigs and imaged with MR. Correlation of histopathology with MR revealed acute mononuclear perivascular inflammatory changes and edema corresponding to the high-intensity abnormalities observed on long repetition time (TR) images. Our results suggest that in acute ...